Analysis performed on 2024-09-30 10:31:03
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 44519 | 798 | 43721 | 11122 |
| Archaea | 3360 | 91 | 3269 | 1434 |
| Vertebrata | 1161 | 312 | 849 | 424 |
| Mammals | 491 | 68 | 423 | 124 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 528 | 29 | 418 |
| Domains | |
|---|---|
| Current Study | 348, 529 |
| Guo et al (2010) | 360, 524 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 346 | 182 | 528 | 1.901099 |
| Number of Variants | 284 | 163 | 447 | 1.742331 |
| Number of Pathogenic Variants | 23 | 6 | 29 | 3.833333 |
| Number of Benign/Unknown Variants | 261 | 157 | 418 | 1.662420 |
| Fisher exact test | 0.074675 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 363 | 165 | 528 | 2.200000 |
| Number of Variants | 303 | 144 | 447 | 2.104167 |
| Number of Pathogenic Variants | 24 | 5 | 29 | 4.800000 |
| Number of Benign/Unknown Variants | 279 | 139 | 418 | 2.007194 |
| Fisher exact test | 0.098910 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 346 | 182 | 0.92 (0.01) | 0.86 (0.01) | 9.575e-01 | 9.123e-01 | 40896.00 | 8.10e-09 |
| Guo et al (2010) | 363 | 165 | 0.91 (0.01) | 0.87 (0.01) | 9.571e-01 | 9.165e-01 | 37190.00 | 4.15e-06 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.